The bacterial replisome has factory-like localization
Sarah M. Mangiameli, Julie A. Cass, Houra Merrikh and Paul A. Wiggins
Current Genetics.
T6SS dynamics reveals a novel secretion mechanism in Pseudomonas aeruginosa
Jacqueline Corbitt, Jun Seok Yeo, C. Ian Davis, Michele LeRoux and Paul A. Wiggins
Journal of Bacteriology 200 (7), JB.00744-17.
Strong disorder leads to scale invariance in complex biological systems
Stella Stylianidou, Thomas J. Lampo, Andrew J. Spakowitz, and Paul A. Wiggins
Physical Review E.
2017
Transcription leads to pervasive replisome instability in bacteria
Sarah M. Mangiameli, Christopher N. Merrikh, Paul A. Wiggins and Houra Merrikh
eLife 6, e19848.
The replisomes remain spatially proximal throughout the cell cycle in bacteria
Sarah M. Mangiameli, Brian T. Veit, Houra Merrikh and Paul A. Wiggins
PLoS Genetics 13 (1), e1006582.
Cytoplasmic RNA-protein particles exhibit non-Gaussian subdiffusive behavior
Thomas J. Lampo, Stella Stylianidou, Mikael P. Backlund, Paul A. Wiggins and Andrew J. Spakowitz.
Biophysical Journal 112(3):532–542
Featured as New and Notable with commentary:
Gaussianity Fair: The Riddle of Anomalous yet Non-Gaussian Diffusion
Ralf Metzler, Biophysical Journal 112(3):413-415
Probing bacterial cell biology using image cytometry
Julie A. Cass, Stella Stylianidou, Nathan J. Kuwada, Beth Traxler and Paul A. Wiggins.
Molecular Microbiology, 103(5): 818–828.
2016
SuperSegger: robust image segmentation, analysis and lineage tracking of bacterial cells
Stella Stylianidou, Connor Brennan, Sila B. Nissen, Nathan J. Kuwada and Paul A. Wiggins.
Molecular Microbiology, 102(4): 690–700.
Escherichia coli chromosomal loci segregate from midcell with universal dynamics
Julie A. Cass, Nathan J. Kuwada, Beth Traxler and Paul A. Wiggins.
Biophysical Journal, 110(12):2597 - 2609.
2015
An information-based approach to change-point analysis with applications to biophysics and cell biology
Paul A. Wiggins. Biophysical Journal 109(2):346-354
High-throughput cell-cycle imaging opens new doors for discovery
Nathan J. Kuwada, Beth Traxler, and Paul A. Wiggins. Current Genetics 1-4
Kin cell lysis is a danger signal that activates antibacterial pathways of Pseudomonas aeruginosa
Michele LeRoux, Robin L. Kirkpatrick, Elena I. Montauti, Bao Q. Tran, S. Brook Peterson, Brittany N. Harding, John C. Whitney, Alistair B. Russell, Beth Traxler, Young Ah Goo, David R. Goodlett, Paul A. Wiggins, and Joseph D. Mougous. eLife 2015;4:e05701
Physical modeling of chromosome segregation in Escherichia coli reveals impact of force and DNA relaxation
Thomas J. Lampo, Nathan J. Kuwada, Paul A. Wiggins, and Andrew J. Spakowitz. Biophysical Journal 108(1):146-153
Featured as New and Notable with commentary: The Ghost in the Machine: Is the Bacterial Chromosome a Phantom Chain? Jian Liu, Biophysical Journal 108(1):20-21
Genome-scale quantitative characterization of bacterial protein localization dynamics throughout the cell cycle
Nathan J. Kuwada, Beth Traxler, and Paul A. Wiggins. Molecular Microbiology 95(1):64-79
Online database for Localizome data can be found here.
2014
Cytoplasmic dynamics reveals two modes of nucleoid-dependent mobility
Stella Stylianidou, Nathan J. Kuwada, and Paul A. Wiggins. Biophysical Journal 107(11):2684-2692
RNA Mango aptamer-fluorophore: A bright, high-affinity complex for RNA labeling and tracking
Elena V. Dolgosheina, Sunny CY Jeng, Shanker Shyam S. Panchapakesan, Razvan Cojocaru, Patrick SK Chen, Peter D. Wilson, Nancy Hawkins, Paul A. Wiggins, and Peter J. Unrau.
ACS Chemical Biology
Unidirectional P-Body transport during the yeast cell cycle
Cecilia Garmendia-Torres, Alexander Skupin, Sean A. Michael, Pekka Ruusuvuori, Nathan J. Kuwada, Didier Falconnet, Gregory A. Cary, Carl Hansen, Paul A. Wiggins,
Aimée M. Dudley. PloS ONE 9(6):e99428
Persistent super-diffusive motion of Escherichia coli chromosomal loci
Avelino Javer, Nathan J. Kuwada, Zhicheng Long, Vincenzo G. Benza, Kevin D. Dorfman, Paul A. Wiggins, Pietro Cicuta, and Marco Cosentino Lagomarsino.
Nature Communications 5
2013
c-di-GMP heterogeneity is generated by the chemotaxis machinery to regulate flagellar motility
Bridget R. Kulasekara, Cassandra Kamischke, Hemantha D. Kulasekara, Matthias Christen, Paul A. Wiggins, Samuel I. Miller. eLife 2:e01402
Estimating podocyte number and density using a single histologic section.
Manhusudan Venkatareddy, Su Wang, Yan Yang, Sanjeevkumar Patel, Larysa Wickman, Ryuzoh Nishizono, Mahboob Chowdhury, Jeffrey Hodgin, Paul A. Wiggins, and Roger C. Wiggins.
Journal of the American Society of Nephrology 25:1118-1129
Diverse type VI secretion phospholipases are functionally plastic antibacterial effectors. Alistair B. Russell, Michele LeRoux, Kristina Hathazi, Danielle M. Agnello, Takahiko Ishikawa, Paul A. Wiggins, Sun Nyunt Wai, and Joseph D. Mougous.
Nature 496:508-512
Calculator for conformational statistics of DNA and applications to high-curvature bending.
Brian C. Ross and Paul A. Wiggins.
Physical Review E 87:032707.
2012
Quantitative single-cell characterization of bacterial interactions reveals type VI secretion is a double-edged sword. Michele LeRoux, Justin A. De Leon, Nathan J. Kuwada, Alistair B. Russell, Delia Pinto-Santini, Rachel D. Hood, Danielle M. Agnello, Stephen M. Robertson, Paul A. Wiggins, and Joseph D. Mougous. PNAS 109:19804-19809.
Multidisciplinary perspectives on bacterial genome organization and dynamics Remus T. Dame, Olivier Espéli, David C. Grainger, and Paul A. Wiggins.
Molecular Microbiology 86:1023-1030.
A single-molecule Hershey-Chase experiment. David Van Valen, David Wu, Yi-Ju Chen, Hannah Tuson, Paul Wiggins, and Rob Phillips.
Current Biology 22:1339-1343.
Measuring chromosome conformation with degenerate labels. Brian C. Ross and Paul A. Wiggins.
Physical Review E 86:011918.
Surface sensing and lateral subcellular localization of WspA, the receptor in a chemosensory-like system leading to c-di-GMP production. Jennifer R. O'Connor, Nathan J. Kuwada, Varisa Huangyutitham, Paul A. Wiggins, and Caroline S. Harwood.
Molecular Microbiology 86:720-729.
A model for Escherichia coli chromosome packaging supports transcription factor-induced DNA domain formation. Miriam Fritsche, Songling Li, Dieter W. Heermann, and Paul A. Wiggins.
Nucleic Acids Research 40:972-980.
2011
Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state. ChristineL Chaffer, Ines Brueckmann, Christina Scheel, AliciaJ Kaestli, Paul A. Wiggins, Leonardo O. Rodrigues, Mary Brooks, Ferenc Reinhardt, Ying Su, Kornelia Polyak, Lisa M Arendt, Charlotte Kuper- wasser, Brian Bierie, and RobertA Weinberg.
PNAS 108:1950-7955
2010
Strong intranucleoid interactions organize the Escherichia coli chromosome into a nucleoid filament. Paul A. Wiggins, Keith C. Cheveralls, Joshua S. Martin, Robert Lintner, and Jan ́e Kondev.
PNAS 107:4991-4995
Mechanosensation in Mechanosensitivity in Cells and Tissues 1: Mechanosensitive Ion Channels T. Ursell, J. Kondev, D. Reeves, P. Wiggins, and R. Phillips. The Role of Lipid Bilayer Mechanics in edited by A. Kamkin and I. Kiseleva, Springer-Verlag, Berlin, Review.
